The effectiveness of long-acting penicillin (penidur) in preventing recurrencies of dermatolymphangioadenitis (DLA) and controlling skin, deep tissues, and lymph bacterial flora in patients with "filarial" lymphedema
Identifieur interne : 008614 ( Main/Exploration ); précédent : 008613; suivant : 008615The effectiveness of long-acting penicillin (penidur) in preventing recurrencies of dermatolymphangioadenitis (DLA) and controlling skin, deep tissues, and lymph bacterial flora in patients with "filarial" lymphedema
Auteurs : W. L. Olszewski [Pologne] ; S. Jamal [Inde] ; G. Manokaran [Inde] ; F. M. Tripathi [Inde] ; M. Zaleska [Pologne] ; E. Stelmach [Pologne]Source :
- Lymphology [ 0024-7766 ] ; 2005.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antibactériens (administration et posologie), Antibactériens (usage thérapeutique), Bactéries (), Bactéries (isolement et purification), Benzathine benzylpénicilline (administration et posologie), Benzathine benzylpénicilline (usage thérapeutique), Femelle, Humains, Inde, Jambe, Liquides biologiques (), Liquides biologiques (microbiologie), Lymphadénite (), Lymphadénite (microbiologie), Lymphadénite (traitement médicamenteux), Lymphangite (), Lymphangite (microbiologie), Lymphangite (traitement médicamenteux), Lymphe (), Lymphe (microbiologie), Lymphoedème (), Lymphoedème (microbiologie), Lymphoedème (traitement médicamenteux), Mâle, Noeuds lymphatiques (), Noeuds lymphatiques (microbiologie), Peau (), Peau (microbiologie), Prévention secondaire, Sujet âgé, Études de cohortes, Études rétrospectives.
- MESH :
- administration et posologie : Antibactériens, Benzathine benzylpénicilline.
- isolement et purification : Bactéries.
- microbiologie : Liquides biologiques, Lymphadénite, Lymphangite, Lymphe, Lymphoedème, Noeuds lymphatiques, Peau.
- traitement médicamenteux : Lymphadénite, Lymphangite, Lymphoedème.
- usage thérapeutique : Antibactériens, Benzathine benzylpénicilline.
- Pascal (Inist)
- Adulte, Adulte d'âge moyen, Appareil circulatoire pathologie, Bactéries, Femelle, Humains, Inde, Jambe, Liquides biologiques, Lymphadénite, Lymphangite, Lymphatique pathologie, Lymphe, Lymphoedème, Mâle, Noeuds lymphatiques, Peau, Prévention secondaire, Pénicilline dérivé, Peau, Lymphe, Flore, Homme, Complication, Sujet âgé, Système lymphatique, Ganglion lymphatique, Dose faible, Membre inférieur, Benzathine benzylpénicilline, Antibiotique, Traitement, Prévalence, Longue durée, Antibactérien, Études de cohortes, Études rétrospectives.
- Wicri :
- geographic : Inde.
- topic : Flore, Homme, Antibiotique.
English descriptors
- KwdEn :
- Adult, Aged, Anti-Bacterial Agents (administration & dosage), Anti-Bacterial Agents (therapeutic use), Antibacterial agent, Antibiotic, Bacteria (drug effects), Bacteria (isolation & purification), Benzathine benzylpenicillin, Body Fluids (drug effects), Body Fluids (microbiology), Cardiovascular disease, Cohort Studies, Complication, Female, Flora, Human, Humans, India, Leg, Long lasting, Low dose, Lower limb, Lymph, Lymph (drug effects), Lymph (microbiology), Lymph Nodes (drug effects), Lymph Nodes (microbiology), Lymph node, Lymphadenitis (drug therapy), Lymphadenitis (microbiology), Lymphadenitis (prevention & control), Lymphangitis (drug therapy), Lymphangitis (microbiology), Lymphangitis (prevention & control), Lymphatic system, Lymphatic vessel disease, Lymphedema, Lymphedema (drug therapy), Lymphedema (microbiology), Lymphedema (prevention & control), Male, Middle Aged, Penicillin G Benzathine (administration & dosage), Penicillin G Benzathine (therapeutic use), Penicillin derivatives, Prevalence, Retrospective Studies, Secondary Prevention, Skin, Skin (drug effects), Skin (microbiology), Treatment.
- MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Penicillin G Benzathine.
- chemical , therapeutic use : Anti-Bacterial Agents, Penicillin G Benzathine.
- geographic : India.
- drug effects : Bacteria, Body Fluids, Lymph, Lymph Nodes, Skin.
- drug therapy : Lymphadenitis, Lymphangitis, Lymphedema.
- isolation & purification : Bacteria.
- microbiology : Body Fluids, Lymph, Lymph Nodes, Lymphadenitis, Lymphangitis, Lymphedema, Skin.
- prevention & control : Lymphadenitis, Lymphangitis, Lymphedema.
- Adult, Aged, Cohort Studies, Female, Humans, Leg, Male, Middle Aged, Retrospective Studies, Secondary Prevention.
Abstract
Dermatolymphangioadenitis (DLA) is a common and serious complication of so-called "filarial" and bacterial non-filarial lymphedema of the limb, affecting skin, lymphatics and lymph nodes. In our previous studies, we demonstrated that more than 60% of patients revealed presence of bacterial isolates in deep tissues, tissue fluid and lymph from the lymphedematous limbs. The question remained open whether elimination or suppression of bacteria dwelling in lymphedematous tissues by administration of low doses of penicillin for long time periods would prevent recurrence of DLA attacks. In this study, we retrospectively evaluated a self/community-selected group of patients with lymphedema of the lower limbs with respect to the efficacy of long-acting penicillin in preventing episodes of DLA. There were no microfilariae or anti-filarial antibodies detected in the investigated group. The questions we asked were: a) how effective is the benzathine penicillin in preventing recurrences of DLA attacks and b) how does its long-term administration influence the bacterial spectrum of leg skin, deep tissues, lymph and lymph nodes and sensitivity to antibiotics. Two randomly selected groups of patients, receiving and not receiving penicillin during the same period of time, were compared. Evidently lower recurrence rate of DLA was observed in the treated group (p<0.002). There was increased prevalence of cocci and gram-positive bacilli with a concomitant decrease of gram-negative bacilli on the foot and calfskin surface. Simultaneously, decreased prevalence of gram-positive cocci and gram-negative bacilli isolates in limb deep tissues and lymph was seen. No resistance to penicillin and other tested antibiotics developed in isolates from the skin surface, deep tissues and lymph. We conclude that long-lasting penicillin is effective in preventing recurrent DLA attacks.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000561
- to stream PascalFrancis, to step Curation: 000399
- to stream PascalFrancis, to step Checkpoint: 000562
- to stream Main, to step Merge: 008838
- to stream PubMed, to step Corpus: 003B92
- to stream PubMed, to step Curation: 003B92
- to stream PubMed, to step Checkpoint: 003B92
- to stream Ncbi, to step Merge: 001F69
- to stream Ncbi, to step Curation: 001F69
- to stream Ncbi, to step Checkpoint: 001F69
- to stream Main, to step Merge: 008060
- to stream Main, to step Curation: 008614
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">The effectiveness of long-acting penicillin (penidur) in preventing recurrencies of dermatolymphangioadenitis (DLA) and controlling skin, deep tissues, and lymph bacterial flora in patients with "filarial" lymphedema</title><author><name sortKey="Olszewski, W L" sort="Olszewski, W L" uniqKey="Olszewski W" first="W. L." last="Olszewski">W. L. Olszewski</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgical Research & Transplantology (WLO,MZ,ES), Medical Research Center, Polish Academy of Sciences</s1><s2>Warsaw</s2><s3>POL</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Jamal, S" sort="Jamal, S" uniqKey="Jamal S" first="S." last="Jamal">S. Jamal</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Thanjavur Medical College (SJ)</s1><s2>Thanjavur</s2><s3>IND</s3><sZ>2 aut.</sZ></inist:fA14><country>Inde</country><wicri:noRegion>Thanjavur Medical College (SJ)</wicri:noRegion></affiliation></author><author><name sortKey="Manokaran, G" sort="Manokaran, G" uniqKey="Manokaran G" first="G." last="Manokaran">G. Manokaran</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Apollo Hospital (GM)</s1><s2>Chennai</s2><s3>IND</s3><sZ>3 aut.</sZ></inist:fA14><country>Inde</country><wicri:noRegion>Apollo Hospital (GM)</wicri:noRegion></affiliation></author><author><name sortKey="Tripathi, F M" sort="Tripathi, F M" uniqKey="Tripathi F" first="F. M." last="Tripathi">F. M. Tripathi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Benares Hindu University (FMT)</s1><s2>Varanasi</s2><s3>IND</s3><sZ>4 aut.</sZ></inist:fA14><country>Inde</country><wicri:noRegion>Benares Hindu University (FMT)</wicri:noRegion></affiliation></author><author><name sortKey="Zaleska, M" sort="Zaleska, M" uniqKey="Zaleska M" first="M." last="Zaleska">M. Zaleska</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgical Research & Transplantology (WLO,MZ,ES), Medical Research Center, Polish Academy of Sciences</s1><s2>Warsaw</s2><s3>POL</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Stelmach, E" sort="Stelmach, E" uniqKey="Stelmach E" first="E." last="Stelmach">E. Stelmach</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgical Research & Transplantology (WLO,MZ,ES), Medical Research Center, Polish Academy of Sciences</s1><s2>Warsaw</s2><s3>POL</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0459138</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0459138 INIST</idno><idno type="RBID">Pascal:05-0459138</idno><idno type="wicri:Area/PascalFrancis/Corpus">000561</idno><idno type="wicri:Area/PascalFrancis/Curation">000399</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000562</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000562</idno><idno type="wicri:doubleKey">0024-7766:2005:Olszewski W:the:effectiveness:of</idno><idno type="wicri:Area/Main/Merge">008838</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:16184816</idno><idno type="wicri:Area/PubMed/Corpus">003B92</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003B92</idno><idno type="wicri:Area/PubMed/Curation">003B92</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003B92</idno><idno type="wicri:Area/PubMed/Checkpoint">003B92</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003B92</idno><idno type="wicri:Area/Ncbi/Merge">001F69</idno><idno type="wicri:Area/Ncbi/Curation">001F69</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F69</idno><idno type="wicri:doubleKey">0024-7766:2005:Olszewski W:the:effectiveness:of</idno><idno type="wicri:Area/Main/Merge">008060</idno><idno type="wicri:Area/Main/Curation">008614</idno><idno type="wicri:Area/Main/Exploration">008614</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The effectiveness of long-acting penicillin (penidur) in preventing recurrencies of dermatolymphangioadenitis (DLA) and controlling skin, deep tissues, and lymph bacterial flora in patients with "filarial" lymphedema</title><author><name sortKey="Olszewski, W L" sort="Olszewski, W L" uniqKey="Olszewski W" first="W. L." last="Olszewski">W. L. Olszewski</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgical Research & Transplantology (WLO,MZ,ES), Medical Research Center, Polish Academy of Sciences</s1><s2>Warsaw</s2><s3>POL</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Jamal, S" sort="Jamal, S" uniqKey="Jamal S" first="S." last="Jamal">S. Jamal</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Thanjavur Medical College (SJ)</s1><s2>Thanjavur</s2><s3>IND</s3><sZ>2 aut.</sZ></inist:fA14><country>Inde</country><wicri:noRegion>Thanjavur Medical College (SJ)</wicri:noRegion></affiliation></author><author><name sortKey="Manokaran, G" sort="Manokaran, G" uniqKey="Manokaran G" first="G." last="Manokaran">G. Manokaran</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Apollo Hospital (GM)</s1><s2>Chennai</s2><s3>IND</s3><sZ>3 aut.</sZ></inist:fA14><country>Inde</country><wicri:noRegion>Apollo Hospital (GM)</wicri:noRegion></affiliation></author><author><name sortKey="Tripathi, F M" sort="Tripathi, F M" uniqKey="Tripathi F" first="F. M." last="Tripathi">F. M. Tripathi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Benares Hindu University (FMT)</s1><s2>Varanasi</s2><s3>IND</s3><sZ>4 aut.</sZ></inist:fA14><country>Inde</country><wicri:noRegion>Benares Hindu University (FMT)</wicri:noRegion></affiliation></author><author><name sortKey="Zaleska, M" sort="Zaleska, M" uniqKey="Zaleska M" first="M." last="Zaleska">M. Zaleska</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgical Research & Transplantology (WLO,MZ,ES), Medical Research Center, Polish Academy of Sciences</s1><s2>Warsaw</s2><s3>POL</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Stelmach, E" sort="Stelmach, E" uniqKey="Stelmach E" first="E." last="Stelmach">E. Stelmach</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgical Research & Transplantology (WLO,MZ,ES), Medical Research Center, Polish Academy of Sciences</s1><s2>Warsaw</s2><s3>POL</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Lymphology</title><title level="j" type="abbreviated">Lymphology</title><idno type="ISSN">0024-7766</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Lymphology</title><title level="j" type="abbreviated">Lymphology</title><idno type="ISSN">0024-7766</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Anti-Bacterial Agents (therapeutic use)</term><term>Antibacterial agent</term><term>Antibiotic</term><term>Bacteria (drug effects)</term><term>Bacteria (isolation & purification)</term><term>Benzathine benzylpenicillin</term><term>Body Fluids (drug effects)</term><term>Body Fluids (microbiology)</term><term>Cardiovascular disease</term><term>Cohort Studies</term><term>Complication</term><term>Female</term><term>Flora</term><term>Human</term><term>Humans</term><term>India</term><term>Leg</term><term>Long lasting</term><term>Low dose</term><term>Lower limb</term><term>Lymph</term><term>Lymph (drug effects)</term><term>Lymph (microbiology)</term><term>Lymph Nodes (drug effects)</term><term>Lymph Nodes (microbiology)</term><term>Lymph node</term><term>Lymphadenitis (drug therapy)</term><term>Lymphadenitis (microbiology)</term><term>Lymphadenitis (prevention & control)</term><term>Lymphangitis (drug therapy)</term><term>Lymphangitis (microbiology)</term><term>Lymphangitis (prevention & control)</term><term>Lymphatic system</term><term>Lymphatic vessel disease</term><term>Lymphedema</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (microbiology)</term><term>Lymphedema (prevention & control)</term><term>Male</term><term>Middle Aged</term><term>Penicillin G Benzathine (administration & dosage)</term><term>Penicillin G Benzathine (therapeutic use)</term><term>Penicillin derivatives</term><term>Prevalence</term><term>Retrospective Studies</term><term>Secondary Prevention</term><term>Skin</term><term>Skin (drug effects)</term><term>Skin (microbiology)</term><term>Treatment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antibactériens (administration et posologie)</term><term>Antibactériens (usage thérapeutique)</term><term>Bactéries ()</term><term>Bactéries (isolement et purification)</term><term>Benzathine benzylpénicilline (administration et posologie)</term><term>Benzathine benzylpénicilline (usage thérapeutique)</term><term>Femelle</term><term>Humains</term><term>Inde</term><term>Jambe</term><term>Liquides biologiques ()</term><term>Liquides biologiques (microbiologie)</term><term>Lymphadénite ()</term><term>Lymphadénite (microbiologie)</term><term>Lymphadénite (traitement médicamenteux)</term><term>Lymphangite ()</term><term>Lymphangite (microbiologie)</term><term>Lymphangite (traitement médicamenteux)</term><term>Lymphe ()</term><term>Lymphe (microbiologie)</term><term>Lymphoedème ()</term><term>Lymphoedème (microbiologie)</term><term>Lymphoedème (traitement médicamenteux)</term><term>Mâle</term><term>Noeuds lymphatiques ()</term><term>Noeuds lymphatiques (microbiologie)</term><term>Peau ()</term><term>Peau (microbiologie)</term><term>Prévention secondaire</term><term>Sujet âgé</term><term>Études de cohortes</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Penicillin G Benzathine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Penicillin G Benzathine</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>India</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antibactériens</term><term>Benzathine benzylpénicilline</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bacteria</term><term>Body Fluids</term><term>Lymph</term><term>Lymph Nodes</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphadenitis</term><term>Lymphangitis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Bacteria</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Bactéries</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Liquides biologiques</term><term>Lymphadénite</term><term>Lymphangite</term><term>Lymphe</term><term>Lymphoedème</term><term>Noeuds lymphatiques</term><term>Peau</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Body Fluids</term><term>Lymph</term><term>Lymph Nodes</term><term>Lymphadenitis</term><term>Lymphangitis</term><term>Lymphedema</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Lymphadenitis</term><term>Lymphangitis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lymphadénite</term><term>Lymphangite</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antibactériens</term><term>Benzathine benzylpénicilline</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Leg</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Secondary Prevention</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Appareil circulatoire pathologie</term><term>Bactéries</term><term>Femelle</term><term>Humains</term><term>Inde</term><term>Jambe</term><term>Liquides biologiques</term><term>Lymphadénite</term><term>Lymphangite</term><term>Lymphatique pathologie</term><term>Lymphe</term><term>Lymphoedème</term><term>Mâle</term><term>Noeuds lymphatiques</term><term>Peau</term><term>Prévention secondaire</term><term>Pénicilline dérivé</term><term>Peau</term><term>Lymphe</term><term>Flore</term><term>Homme</term><term>Complication</term><term>Sujet âgé</term><term>Système lymphatique</term><term>Ganglion lymphatique</term><term>Dose faible</term><term>Membre inférieur</term><term>Benzathine benzylpénicilline</term><term>Antibiotique</term><term>Traitement</term><term>Prévalence</term><term>Longue durée</term><term>Antibactérien</term><term>Études de cohortes</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Flore</term><term>Homme</term><term>Antibiotique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dermatolymphangioadenitis (DLA) is a common and serious complication of so-called "filarial" and bacterial non-filarial lymphedema of the limb, affecting skin, lymphatics and lymph nodes. In our previous studies, we demonstrated that more than 60% of patients revealed presence of bacterial isolates in deep tissues, tissue fluid and lymph from the lymphedematous limbs. The question remained open whether elimination or suppression of bacteria dwelling in lymphedematous tissues by administration of low doses of penicillin for long time periods would prevent recurrence of DLA attacks. In this study, we retrospectively evaluated a self/community-selected group of patients with lymphedema of the lower limbs with respect to the efficacy of long-acting penicillin in preventing episodes of DLA. There were no microfilariae or anti-filarial antibodies detected in the investigated group. The questions we asked were: a) how effective is the benzathine penicillin in preventing recurrences of DLA attacks and b) how does its long-term administration influence the bacterial spectrum of leg skin, deep tissues, lymph and lymph nodes and sensitivity to antibiotics. Two randomly selected groups of patients, receiving and not receiving penicillin during the same period of time, were compared. Evidently lower recurrence rate of DLA was observed in the treated group (p<0.002). There was increased prevalence of cocci and gram-positive bacilli with a concomitant decrease of gram-negative bacilli on the foot and calfskin surface. Simultaneously, decreased prevalence of gram-positive cocci and gram-negative bacilli isolates in limb deep tissues and lymph was seen. No resistance to penicillin and other tested antibiotics developed in isolates from the skin surface, deep tissues and lymph. We conclude that long-lasting penicillin is effective in preventing recurrent DLA attacks.</div></front></TEI><affiliations><list><country><li>Inde</li><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Olszewski, W L" sort="Olszewski, W L" uniqKey="Olszewski W" first="W. L." last="Olszewski">W. L. Olszewski</name></noRegion><name sortKey="Stelmach, E" sort="Stelmach, E" uniqKey="Stelmach E" first="E." last="Stelmach">E. Stelmach</name><name sortKey="Zaleska, M" sort="Zaleska, M" uniqKey="Zaleska M" first="M." last="Zaleska">M. Zaleska</name></country><country name="Inde"><noRegion><name sortKey="Jamal, S" sort="Jamal, S" uniqKey="Jamal S" first="S." last="Jamal">S. Jamal</name></noRegion><name sortKey="Manokaran, G" sort="Manokaran, G" uniqKey="Manokaran G" first="G." last="Manokaran">G. Manokaran</name><name sortKey="Tripathi, F M" sort="Tripathi, F M" uniqKey="Tripathi F" first="F. M." last="Tripathi">F. M. Tripathi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008614 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008614 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:05-0459138
|texte= The effectiveness of long-acting penicillin (penidur) in preventing recurrencies of dermatolymphangioadenitis (DLA) and controlling skin, deep tissues, and lymph bacterial flora in patients with "filarial" lymphedema
}}
| This area was generated with Dilib version V0.6.31. |  |